I recently had a writing expert tell me a robot cannot be a protagonist.  Earlier this expert said God can't be a protagonist.  Only now do I understand what he was getting at, namely, a protagonist must have something to lose.  There must be something on the line.  There must be the possibility that he/she/it can fail. This is hard to imagine with the Judeo-Christian G-O-D, omniscient and omnipotent.  However, I have read stories with God as the protagonist; this God could fail, so I guess technically it was not The Judeo-Christian God.  Similarly, the robot in question was sentient, it had intelligence, feelings/emotions, hopes/dreams, and could die.  So, I say this robot could also be a protagonist.  Can a random non-sentient machine be a protagonist?  No.  Can a ghost or other supernatural creature be a protagonist?  Yes, if he/she/it can act and had something to lose.      
What do you think?
For more on my take on protagonists see: P is for Protagonist.